Anti-DSPP Antibody

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Product name Anti-DSPP Antibody
Short Description Rabbit polyclonal against DSPP
Description This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Dentin sialophosphoprotein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 16-146 of human DSPP (NP_055023.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1834
Gene Symbol DSPP
Molecular Weight 131.151 kDa
Database Links HGNC:3054
Alternative Names Dentin sialophosphoprotein
Function DSP may be an important factor in dentinogenesis, DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals
Post-translational Modifications DSP is glycosylated
Cellular Localization Secreted, extracellular space, extracellular matrix
Tissue Specificity Expressed in teeth, DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts
Swiss-Prot Key Q9NZW4
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Ren J, Liang G, Gong L, Guo B, Jiang H. Rac1 Regulates the Proliferation, Adhesion, Migration, and Differentiation of MDPC-23 Cells. 16FEB2017. Regenerative Endodontics.  doi:10.1016/j.joen.2016.11.016

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