Anti-EEA1 antibody

[STJ96393] Download PDF Print Data Sheet
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Product name Anti-EEA1 antibody
Short Description Rabbit polyclonal to EEA1.
Description EEA1 is a protein encoded by the EEA1 gene which is approximately 162,5 kDa. EEA1 is localised to the cytoplasm and is involved in the innate immune system, activated TLR4 signalling and sorting endosome formation in CF. It binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. EEA1 is expressed in the liver, eye, heart, pancreas and adrenal gland. Mutations in the EEA1 gene may result in Bartonellosis and Cutaneous Lupus Erythematosus. STJ96393 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of EEA1 protein.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity EEA1 Polyclonal Antibody detects endogenous levels of EEA1 protein.
Protein Name Early endosome antigen 1
Endosome-associated protein p162
Zinc finger FYVE domain-containing protein 2
Immunogen Synthesized peptide derived from human EEA1.
Immunogen Region N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8411
Gene Symbol EEA1
Molecular Weight 162 kDa
Database Links HGNC:3185
OMIM:605070
Alternative Names Early endosome antigen 1 antibody
Endosome-associated protein p162 antibody
Zinc finger FYVE domain-containing protein 2 antibody
ZFYVE2 antibody
Function Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Cellular Localization Cytoplasm. Early endosome membrane. Peripheral membrane protein.
Sequence and Domain Family The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Swiss-Prot Key Q15075_HUMAN
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