Anti-EHHADH antibody

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Product name Anti-EHHADH antibody
Short Description Rabbit polyclonal against EHHADH
Description The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Peroxisomal Bifunctional Enzyme
Pbe
Pbfe [Includes - Enoyl-Coa Hydratase/3 -2-Trans-Enoyl-Coa Isomerase - 3-Hydroxyacyl-Coa Dehydrogenase ]
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 444-723 of human EHHADH (NP_001957. 2).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1962
Gene Symbol EHHADH
Molecular Weight Calculated: 69kDa/79kDa. Observed: 79kDa
Alternative Names Anti-Peroxisomal Bifunctional Enzyme antibody
Anti-Pbe antibody
Anti-Pbfe [Includes - Enoyl-Coa Hydratase/3 -2-Trans-Enoyl-Coa Isomerase - 3-Hydroxyacyl-Coa Dehydrogenase ] antibody
Anti-EHHADH ECHD antibody
Post-translational Modifications Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with highest increase on Lys-346. Acetylation and enzyme activity increased by about 1. 5% on addition of fatty acids.
Cellular Localization Peroxisome
Tissue Specificity Liver and kidney. Strongly expressed in the terminal segments of the proximal tubule. Lower amounts seen in the brain.
Swiss-Prot Key ECHP_HUMAN
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