Anti-EHHADH Antibody

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Product name Anti-EHHADH Antibody
Short Description Rabbit polyclonal against EHHADH
Description The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Peroxisomal bifunctional enzyme
PBE
PBFE
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 444-723 of human EHHADH (NP_001957.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1962
Gene Symbol EHHADH
Molecular Weight 79.495 kDa
Database Links HGNC:3247
OMIM:607037
Reactome:R-HSA-390247
Alternative Names Peroxisomal bifunctional enzyme
PBE
PBFE
Post-translational Modifications Acetylated, leading to enhanced enzyme activity, Acetylation is enhanced by up to 80% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with highest increase on Lys-346, Acetylation and enzyme activity increased by about 1,5% on addition of fatty acids,
Cellular Localization Peroxisome
Tissue Specificity Liver and kidney, Strongly expressed in the terminal segments of the proximal tubule, Lower amounts seen in the brain
Swiss-Prot Key Q08426
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