| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ELF4 (1-200) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ELF4 |
| Gene ID: |
2000 |
| Uniprot ID: |
ELF4_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ELF4 (NP_001412.1). |
| Immunogen Sequence: |
MAITLQPSDLIFEFASNGMD DDIHQLEDPSVFPAVIVEQV PYPDLLHLYSGLELDDVHNG IITDGTLCMTQDQILEGSFL LTDDNEATSHTMSTAEVLLN MESPSDILDEKQIFSTSEML PDSDPAPAVTLPNYLFPASE PDALNRAGDTSDQEGHSLEE KASREESAKKTGKSKKRIRK TKGNRSTSPVTDPSIPIRKK |
| Tissue Specificity | Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. |
| Function | Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN. Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1. Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses. |
| Protein Name | Ets-Related Transcription Factor Elf-4E74-Like Factor 4Myeloid Elf-1-Like Factor |
| Cellular Localisation | NucleusPml BodyAccumulation Into Pml Nuclear Bodies Is Mediated By Pml |
| Alternative Antibody Names | Anti-Ets-Related Transcription Factor Elf-4 antibodyAnti-E74-Like Factor 4 antibodyAnti-Myeloid Elf-1-Like Factor antibodyAnti-ELF4 antibodyAnti-ELFR antibodyAnti-MEF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
