| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ENPP4 (90-230) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ENPP4 |
| Gene ID: |
22875 |
| Uniprot ID: |
ENPP4_HUMAN |
| Immunogen Region: |
90-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-230 of human ENPP4 (NP_055751.1). |
| Immunogen Sequence: |
ANSMYDAVTKKHFSDSNDKD PFWWNEAVPIWVTNQLQENR SSAAAMWPGTDVPIHDTISS YFMNYNSSVSFEERLNNITM WLNNSNPPVTFATLYWEEPD ASGHKYGPEDKENMSRVLKK IDDLIGDLVQRLKMLGLWEN L |
| Tissue Specificity | Expressed on the surface of vascular endothelia. |
| Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. |
| Protein Name | Bis(5'-Adenosyl-Triphosphatase Enpp4Ap3a HydrolaseAp3aaseEctonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4E-Npp 4Npp-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bis(5'-Adenosyl-Triphosphatase Enpp4 antibodyAnti-Ap3a Hydrolase antibodyAnti-Ap3aase antibodyAnti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4 antibodyAnti-E-Npp 4 antibodyAnti-Npp-4 antibodyAnti-ENPP4 antibodyAnti-KIAA0879 antibodyAnti-NPP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Prion Protein knockout (KO) HeLa cells, using [KO Validated] Prion Protein Rabbit polyclonal antibody (STJ11100031) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89103/357560/STJ11100031_1__14868.1713121685.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Prion Protein knockout (KO) HeLa cells, using [KO Validated] Prion Protein Rabbit polyclonal antibody (STJ11100031) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")
