Anti-ERBB2 antibody

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Product name Anti-ERBB2 antibody
Short Description Mouse monoclonal to ERBB2
Description The Her2/Neu (c-erbB-2) proto-oncogene is a transmembrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the c-erbB-2 protein has been associated with ductal breast cancer, as well as pulmonary and gastric adenocarcinomas. A correlation between Her2 and p53 has also been documented, as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.
Applications IHC
Dilution range 1:100 - 1:200
Protein Name Receptor tyrosine-protein kinase erbB-2
Immunogen Human Her2/Neu protein.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC
Host Mouse
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Formulation Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Gene ID 2064
Gene Symbol ERBB2
Molecular Weight 138 kDa
Database Links HGNC:3430
OMIM:137800
Reactome:R-HSA-1227986
Alternative Names Receptor tyrosine-protein kinase erbB-2 antibody
HER2 antibody
MLN19 antibody
NEU antibody
NGL antibody
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding, Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone, GP30 is a potential ligand for this receptor, Regulates outgrowth and stabilization of peripheral microtubules (MTs), Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane, In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Post-translational Modifications Autophosphorylated, Autophosphorylation occurs in trans, i,e, one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable), Ligand-binding increases phosphorylation on tyrosine residues
Cellular Localization Cell membrane
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Swiss-Prot Key P04626
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