Anti-ERBB2 antibody

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Product name Anti-ERBB2 antibody
Short Description Rabbit monoclonal to ERBB2
Description c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
Applications IHC
Dilution range 1:200-300
Protein Name Receptor tyrosine-protein kinase erbB-2
Immunogen Recombinant protein encoding extracellular domain of human c-erbB2
Storage Instruction Store at 2-8°C for up to 1 year
Note For Research Use Only (RUO).
Validated Application IHC
Host Rabbit
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Isotype IgG
Formulation Tissue culture supernatant with 0.2% BSA and 15mM sodium azide.
Gene ID 2064
Gene Symbol ERBB2
Molecular Weight 138 kDa
Database Links HGNC:3430
OMIM:137800
Reactome:R-HSA-1227986
Alternative Names Receptor tyrosine-protein kinase erbB-2 antibody
HER2 antibody
MLN19 antibody
NEU antibody
NGL antibody
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding, Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone, GP30 is a potential ligand for this receptor, Regulates outgrowth and stabilization of peripheral microtubules (MTs), Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane, In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization,
Post-translational Modifications Autophosphorylated, Autophosphorylation occurs in trans, i,e, one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable), Ligand-binding increases phosphorylation on tyrosine residues.
Cellular Localization Cell membrane
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Swiss-Prot Key P04626
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