Anti-ERLIN1 Antibody

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Product name Anti-ERLIN1 Antibody
Short Description Rabbit polyclonal against ERLIN1
Description The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Erlin-1
Endoplasmic reticulum lipid raft-associated protein 1
Protein KE04
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
SPFH domain-containing protein 1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 259-348 of human ERLIN1 (NP_006450.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 10613
Gene Symbol ERLIN1
Molecular Weight 38.926 kDa
Database Links HGNC:16947
OMIM:611604
Reactome:R-HSA-382556
Alternative Names Erlin-1
Endoplasmic reticulum lipid raft-associated protein 1
Protein KE04
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1
SPFH domain-containing protein 1
Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs), Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway, Binds cholesterol and may promote ER retention of the SCAP-SREBF complex ,
Cellular Localization Endoplasmic reticulum membrane,
Tissue Specificity Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine
Swiss-Prot Key O75477
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