Anti-EXO1 Antibody

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Product name Anti-EXO1 Antibody
Short Description Rabbit polyclonal against EXO1
Description This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.
Applications IF, WB
Dilution range WB 1:500 - 1:1000
IF 1:20 - 1:50
Protein Name Exonuclease 1
hExo1
Immunogen A synthetic peptide of human EXO1
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IF
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 9156
Gene Symbol EXO1
Molecular Weight 94.103 kDa
Database Links HGNC:3511
OMIM:606063
Reactome:R-HSA-5358565
Alternative Names Exonuclease 1
hExo1
Function 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity, Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch, Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment, Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes, Essential for male and female meiosis,
Post-translational Modifications Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR, Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment, The HU-induced EXO1 triple phosphorylation facilitates destabilisation/degradation of the protein,
Cellular Localization Nucleus,
Tissue Specificity Highly expressed in bone marrow, testis and thymus, Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach
Swiss-Prot Key Q9UQ84
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