| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EYA2 (300-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EYA2 |
| Gene ID: |
2139 |
| Uniprot ID: |
EYA2_HUMAN |
| Immunogen Region: |
300-400 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human EYA2 (NP_005235.3). |
| Immunogen Sequence: |
TSVRIGLMMEEMIFNLADTH LFFNDLEDCDQIHVDDVSSD DNGQDLSTYNFSADGFHSSA PGANLCLGSGVHGGVDWMRK LAFRYRRVKEMYNTYKNNVG G |
| Tissue Specificity | Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart. |
| Function | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2.in this it is functionally redundant with EYA1. |
| Protein Name | Eyes Absent Homolog 2 |
| Database Links | Reactome: R-HSA-5693565 |
| Cellular Localisation | CytoplasmNucleusRetained In The Cytoplasm Via Interaction With Gnaz And Gnai2Interaction With Six1Six2Six4 Or Six5 Is Required For Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Eyes Absent Homolog 2 antibodyAnti-EYA2 antibodyAnti-EAB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
