| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EZH1 (160-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EZH1 |
| Gene ID: |
2145 |
| Uniprot ID: |
EZH1_HUMAN |
| Immunogen Region: |
160-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-270 of EZH1 (NP_001982.2). |
| Immunogen Sequence: |
GEEEMIPGSVLISDAVFLEL VDALNQYSDEEEEGHNDTSD GKQDDSKEDLPVTRKRKRHA IEGNKKSSKKQFPNDMIFSA IASMFPENGVPDDMKERYRE LTEMSDPNALP |
| Function | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
| Protein Name | Histone-Lysine N-Methyltransferase Ezh1Enx-2Enhancer Of Zeste Homolog 1 |
| Cellular Localisation | NucleusColocalizes With Trimethylated 'Lys-27' Of Histone H3 |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Ezh1 antibodyAnti-Enx-2 antibodyAnti-Enhancer Of Zeste Homolog 1 antibodyAnti-EZH1 antibodyAnti-KIAA0388 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
