Anti-FAAH Antibody

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Product name Anti-FAAH Antibody
Short Description Rabbit polyclonal against FAAH
Description This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Fatty-acid amide hydrolase 1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 450-579 of human FAAH (NP_001432.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2166
Gene Symbol FAAH
Molecular Weight 63.066 kDa
Database Links HGNC:3553
OMIM:602935
Reactome:R-HSA-2142753
Alternative Names Fatty-acid amide hydrolase 1
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules, Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates,
Cellular Localization Endomembrane system,
Tissue Specificity Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis, Also expressed in the kidney, liver, lung, placenta and prostate
Swiss-Prot Key O00519
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Natalia Malek, Magdalena Kostrzewa, Wioletta Makuch,  Agnieszka Pajak, Mateusz Kucharczyk, Fabiana Piscitelli, Barbara Przewlocka, Vincenzo Di Marzo, Katarzyna Starowicz. "The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain". Pharmacological Research Volume 111, September 2016, Pages 251–263.  doi:10.1016/j.phrs.2016.06.012

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