Anti-Gasdermin C antibody

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Product name Anti-Gasdermin C antibody
Short Description Rabbit polyclonal against Gasdermin C
Description Rabbit polyclonal to Gasdermin C.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:10000
Specificity Gasdermin C Polyclonal Antibody detects endogenous levels of Gasdermin C protein.
Protein Name Gasdermin-C
Melanoma-derived leucine zipper-containing extranuclear factor
Immunogen Synthesized peptide derived from human Gasdermin C
Immunogen Region 80-160 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 56169
Gene Symbol GSDMC
Molecular Weight 55 kDa
Database Links HGNC:7151
Alternative Names Gasdermin-C
Melanoma-derived leucine zipper-containing extranuclear factor
Function The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores . The physiological relevance of this observation is unknown (Probable).
Cellular Localization Cytoplasm, cytosol Cell membrane
Tissue Specificity Expressed mainly in trachea and spleen . In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium .
Sequence and Domain Family Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.
Swiss-Prot Key Q9BYG8_HUMAN
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Kusumaningrum, Novi Lee, Dong Hun Yoon, Hyun-Sun, Kim, Yeon Kyung, Park Chi-Hyun, Chung, Jin Ho. Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways. Journal of Dermatological Science (2018).

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