| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GAST (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GAST |
| Gene ID: |
2520 |
| Uniprot ID: |
GAST_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GAST (NP_000796.1). |
| Immunogen Sequence: |
MQRLCVYVLIFALALAAFSE ASWKPRSQQPDAPLGTGANR DLELPWLEQQGPASHHRRQL GPQGPPHLVADPSKKQGPWL EEEEEAYGWMDFGRRSAEDE |
| Post Translational Modifications | Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. |
| Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| Protein Name | Gastrin Cleaved Into - Gastrin-71Gastrin Component I - Gastrin-52G52 - Big GastrinGastrin Component IiGastrin-34G34 - GastrinGastrin Component IiiGastrin-17G17 - Gastrin-14G14 - Gastrin-6G6 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-881907 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Gastrin Cleaved Into - Gastrin-71 antibodyAnti-Gastrin Component I - Gastrin-52 antibodyAnti-G52 - Big Gastrin antibodyAnti-Gastrin Component Ii antibodyAnti-Gastrin-34 antibodyAnti-G34 - Gastrin antibodyAnti-Gastrin Component Iii antibodyAnti-Gastrin-17 antibodyAnti-G17 - Gastrin-14 antibodyAnti-G14 - Gastrin-6 antibodyAnti-G6 antibodyAnti-GAST antibodyAnti-GAS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
