| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GC (324-493) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GC |
| Gene ID: |
2638 |
| Uniprot ID: |
VTDB_HUMAN |
| Immunogen Region: |
324-493 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 324-493 of human Vitamin D Binding protein (NP_001191236.1). |
| Immunogen Sequence: |
AMDVFVCTYFMPAAQLPELP DVELPTNKDVCDPGNTKVMD KYTFELSRRTHLPEVFLSKV LEPTLKSLGECCDVEDSTTC FNAKGPLLKKELSSFIDKGQ ELCADYSENTFTEYKKKLAE RLKAKLPDATPTELAKLVNK HSDFASNCCSINSPPLYCDS EIDAELKNIL |
| Tissue Specificity | Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. |
| Post Translational Modifications | Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. |
| Function | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. |
| Protein Name | Vitamin D-Binding ProteinDbpVdbGc Protein-Derived Macrophage Activating FactorGc-MafGcmafGc-GlobulinGroup-Specific ComponentGcVitamin D-Binding Protein-Macrophage Activating FactorDbp-Maf |
| Database Links | Reactome: R-HSA-196791 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vitamin D-Binding Protein antibodyAnti-Dbp antibodyAnti-Vdb antibodyAnti-Gc Protein-Derived Macrophage Activating Factor antibodyAnti-Gc-Maf antibodyAnti-Gcmaf antibodyAnti-Gc-Globulin antibodyAnti-Group-Specific Component antibodyAnti-Gc antibodyAnti-Vitamin D-Binding Protein-Macrophage Activating Factor antibodyAnti-Dbp-Maf antibodyAnti-GC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
