Anti-GCLM Antibody

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Anti-GCLM Antibody

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Product name Anti-GCLM Antibody
Short Description Rabbit polyclonal against GCLM
Description Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Glutamate--cysteine ligase regulatory subunit
GCS light chain
Gamma-ECS regulatory subunit
Gamma-glutamylcysteine synthetase regulatory subunit
Glutamate--cysteine ligase modifier subunit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2730
Gene Symbol GCLM
Molecular Weight 30.727 kDa
Database Links HGNC:4312
OMIM:601176
Reactome:R-HSA-174403
Alternative Names Glutamate--cysteine ligase regulatory subunit
GCS light chain
Gamma-ECS regulatory subunit
Gamma-glutamylcysteine synthetase regulatory subunit
Glutamate--cysteine ligase modifier subunit
Tissue Specificity In all tissues examined, Highest levels in skeletal muscle
Swiss-Prot Key P48507
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