Anti-GCLM antibody

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Product name Anti-GCLM antibody
Short Description Rabbit polyclonal against GCLM
Description Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications IF, WB
Dilution range WB 1:500-1:2000 IF 1:50-1:200
Protein Name Glutamate--Cysteine Ligase Regulatory Subunit
Gcs Light Chain
Gamma-Ecs Regulatory Subunit
Gamma-Glutamylcysteine Synthetase Regulatory Subunit
Glutamate--Cysteine Ligase Modifier Subunit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human GCLM (NP_002052. 1).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2730
Gene Symbol GCLM
Molecular Weight Calculated: 28kDa/30kDa. Observed: 31kDa
Database Links Reactome: R-HSA-174403
Alternative Names Anti-Glutamate--Cysteine Ligase Regulatory Subunit antibody
Anti-Gcs Light Chain antibody
Anti-Gamma-Ecs Regulatory Subunit antibody
Anti-Gamma-Glutamylcysteine Synthetase Regulatory Subunit antibody
Anti-Glutamate--Cysteine Ligase Modifier Subunit antibody
Anti-GCLM GLCLR antibody
Tissue Specificity In all tissues examined. Highest levels in skeletal muscle.
Swiss-Prot Key GSH0_HUMAN
Bad Good
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