| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GP6 (21-267) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GP6 |
| Gene ID: |
51206 |
| Uniprot ID: |
GPVI_HUMAN |
| Immunogen Region: |
21-267 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 21-267 of human GP6 (NP_057447.5). |
| Immunogen Sequence: |
QSGPLPKPSLQALPSSLVPL EKPVTLRCQGPPGVDLYRLE KLSSSRYQDQAVLFIPAMKR SLAGRYRCSYQNGSLWSLPS DQLELVATGVFAKPSLSAQP GPAVSSGGDVTLQCQTRYGF DQFALYKEGDPAPYKNPERW YRASFPIITVTAAHSGTYRC YSFSSRDPYLWSAPSDPLEL VVTGTSVTPSRLPTEPPSPV AEFSEATAELTVSFTNEVFT TETSRSITASPKESDSPAG |
| Tissue Specificity | Megakaryocytes and platelets. |
| Post Translational Modifications | N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 6 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-75892 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Vi antibodyAnti-Gpvi antibodyAnti-Glycoprotein 6 antibodyAnti-GP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
