| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPC6 (320-530) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPC6 |
| Gene ID: |
10082 |
| Uniprot ID: |
GPC6_HUMAN |
| Immunogen Region: |
320-530 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 320-530 of human GPC6 (NP_005699.1). |
| Immunogen Sequence: |
SEAIMNMQENSMQVSAKVFQ GCGQPKPAPALRSARSAPEN FNTRFRPYNPEERPTTAAGT SLDRLVTDIKEKLKLSKKVW SALPYTICKDESVTAGTSNE EECWNGHSKARYLPEIMNDG LTNQINNPEVDVDITRPDTF IRQQIMALRVMTNKLKNAYN GNDVNFQDTSDESSGSGSGS GCMDDVCPTEFEFVTTEAPA VDPDRREVDSS |
| Tissue Specificity | Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level). |
| Function | Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling. |
| Protein Name | Glypican-6 Cleaved Into - Secreted Glypican-6 |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-2022928Reactome: R-HSA-2024096Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3656237Reactome: R-HSA-3656253Reactome: R-HSA-4420332Reactome: R-HSA-9694614Reactome: R-HSA-975634 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideSecreted Glypican-6: SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Glypican-6 Cleaved Into - Secreted Glypican-6 antibodyAnti-GPC6 antibodyAnti-UNQ369 antibodyAnti-PRO705 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
