Anti-GPM6A antibody

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Product name Anti-GPM6A antibody
Short Description Rabbit polyclonal against GPM6A
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Neuronal Membrane Glycoprotein M6-A
M6a
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 159-278 of human GPM6A (NP_005268. 1).
Storage Instruction Store at -20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Gene ID 2823
Gene Symbol GPM6A
Molecular Weight Calculated: 29kDa/30kDa/31kDa. Observed: 31kDa
Alternative Names Anti-Neuronal Membrane Glycoprotein M6-A antibody
Anti-M6a antibody
Anti-GPM6A M6A antibody
Function Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs).enhances internalization and recycling of mu-type opioid receptor.
Cellular Localization Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Axon
Growth Cone
Dendritic Spine
Filopodium
Neuron Projection
Localizes To Cholesterol-Rich Lipid Rafts Of The Plasma Membrane Of Hippocampal Neurons
Localized To Plasma Membrane Of Cell Bodies And Neurites Of Hippocampal Neurons
Localized In Membrane Protrusions (Filopodia And Spines) Of Primary Hippocampal Neurons
Localized To The Growth Cone Edge Membrane Of Elongating Axons
Swiss-Prot Key GPM6A_HUMAN
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