| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRIA1 (330-470) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIA1 |
| Gene ID: |
2890 |
| Uniprot ID: |
GRIA1_HUMAN |
| Immunogen Region: |
330-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 330-470 of human GluR1/GRIA1 (NP_000818.2). |
| Immunogen Sequence: |
PWGQGIDIQRALQQVRFEGL TGNVQFNEKGRRTNYTLHVI EMKHDGIRKIGYWNEDDKFV PAATDAQAGGDNSSVQNRTY IVTTILEDPYVMLKKNANQF EGNDRYEGYCVELAAEIAKH VGYSYRLEIVSDGKYGARDP D |
| Tissue Specificity | Widely expressed in brain. |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation. |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 1Glur-1Ampa-Selective Glutamate Receptor 1Glur-AGlur-K1Glutamate Receptor Ionotropic - Ampa 1Glua1 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-5694530Reactome: R-HSA-8849932Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembranePostsynaptic Cell MembranePostsynaptic Density MembraneCell ProjectionDendriteDendritic SpineEarly Endosome MembraneRecycling Endosome MembranePresynapseSynapseInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionColocalizes With Pdlim4 In Early EndosomesDisplays A Somatodendritic Localization And Is Excluded From Axons In NeuronsLocalized To Cone Photoreceptor Pedicles |
| Alternative Antibody Names | Anti-Glutamate Receptor 1 antibodyAnti-Glur-1 antibodyAnti-Ampa-Selective Glutamate Receptor 1 antibodyAnti-Glur-A antibodyAnti-Glur-K1 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 1 antibodyAnti-Glua1 antibodyAnti-GRIA1 antibodyAnti-GLUH1 antibodyAnti-GLUR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
