| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRIPAP1 (642-841) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIPAP1 |
| Gene ID: |
56850 |
| Uniprot ID: |
GRAP1_HUMAN |
| Immunogen Region: |
642-841 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 642-841 of human GRIPAP1 (NP_064522.3). |
| Immunogen Sequence: |
RSGLEELVLSEMNSPSRTQT GDSSSISSFSYREILREKES SAVPARSLSSSPQAQPPRPA ELSDEEVAELFQRLAETQQE KWMLEEKVKHLEVSSASMAE DLCRKSAIIETYVMDSRIDV SVAAGHTDRSGLGSVLRDLV KPGDENLREMNKKLQNMLEE QLTKNMHLHKDMEVLSQEIV RLSKECVGPPDPDLEPGETS |
| Post Translational Modifications | Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation. |
| Function | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. |
| Protein Name | Grip1-Associated Protein 1Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain30kda C-Terminus Form |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinRecycling Endosome MembraneCell ProjectionAxonDendriteSynapseLocalizes To Recycling Endosomal Tubules That Are Emanating From Early Endosomes |
| Alternative Antibody Names | Anti-Grip1-Associated Protein 1 antibodyAnti-Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain antibodyAnti-30kda C-Terminus Form antibodyAnti-GRIPAP1 antibodyAnti-KIAA1167 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
