Anti-GRM3 Antibody

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Product name Anti-GRM3 Antibody
Short Description Rabbit polyclonal against GRM3
Description L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Metabotropic glutamate receptor 3
mGluR3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 23-170 of human GRM3 (NP_000831.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2913
Gene Symbol GRM3
Molecular Weight 98.879 kDa
Database Links HGNC:4595
OMIM:601115
Reactome:R-HSA-418594
Alternative Names Metabotropic glutamate receptor 3
mGluR3
Function G-protein coupled receptor for glutamate, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, Signaling inhibits adenylate cyclase activity,
Cellular Localization Cell membrane
Tissue Specificity Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala
Swiss-Prot Key Q14832
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