• Western blot analysis of extracts of Rat heart, using HFE2 rabbit polyclonal antibody (STJ27301) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-HFE2 antibody (1-200) (STJ27301)

SKU:
STJ27301

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-HFE2 (1-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HJV
Gene ID: 148738
Uniprot ID: RGMC_HUMAN
Immunogen Region: 1-200
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HFE2 (NP_998817.1).
Immunogen Sequence: MQECIDQKVYQAEVDNLPVA FEDGSINGGDRPGGSSLSIQ TANPGNHVEIQAAYIGTTII IRQTAGQLSFSIKVAEDVAM AFSAEQDLQLCVGGCPPSQR LSRSERNRRGAITIDTARRL CKEGLPVEDAYFHSCVFDVL ISGDPNFTVAAQAALEDARA FLPDLEKLHLFPSD
Tissue Specificity Adult and fetal liver, heart, and skeletal muscle.
Post Translational Modifications Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis.
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Protein Name Hemojuvelin
Hemochromatosis Type 2 Protein
Hemojuvelin Bmp Coreceptor
Rgm Domain Family Member C
Database Links Reactome: R-HSA-373752
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Also Released In The Extracellular Space
Alternative Antibody Names Anti-Hemojuvelin antibody
Anti-Hemochromatosis Type 2 Protein antibody
Anti-Hemojuvelin Bmp Coreceptor antibody
Anti-Rgm Domain Family Member C antibody
Anti-HJV antibody
Anti-HFE2 antibody
Anti-RGMC antibody

Information sourced from Uniprot.org

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