Anti-HOOK1 antibody

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Product name Anti-HOOK1 antibody
Short Description Rabbit polyclonal against HOOK1
Description This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Protein Hook Homolog 1
H-Hook1
Hhk1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 489-728 of human HOOK1 (NP_056972. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 51361
Gene Symbol HOOK1
Molecular Weight Calculated: 80kDa/84kDa. Observed: 85-100kDa
Alternative Names Anti-Protein Hook Homolog 1 antibody
Anti-H-Hook1 antibody
Anti-Hhk1 antibody
Anti-HOOK1 antibody
Function Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).
Cellular Localization Cytoplasm
Cytoskeleton
Localizes To Punctate Cytoplasmic Foci Which Do Not Appear To Overlap With Early Or Late Endosomes
The Endoplasmic Reticulum
Multivesicular Bodies (Mvbs)
Lysosomes
Or Mitochondria (By Similarity)
Often Found In Close Association With Microtubules (By Similarity)
Does Not Associate With The Golgi Complex
During Spermiogenesis
It Localizes To The Manchette In Spermatids From Steps 8-10
It Is Also Present Between The Microtubule Manchette And The Nucleus
During Manchette Elongation
It Is Preferentially Localized To The Nuclear Ring Of The Manchette
Whereas The Strong Localization To The Manchette Decreases
In More Mature Spermatids
While The Manchette Migrates Posteriorly
It Localizes To Punctuates Spots
At Later Stages Of Spermatid Differentiation
The Punctuate Expression Pattern Is Found At Both The Attachment Site And The Proximal End Of The Elongated Manchette
In Contrast
It Is Not Present In Mature Spermatozoa (By Similarity)
Swiss-Prot Key HOOK1_HUMAN
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