Anti-HOOK1 Antibody

[STJ26831] Download PDF Print Data Sheet

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Product name Anti-HOOK1 Antibody
Short Description Rabbit polyclonal against HOOK1
Description This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Protein Hook homolog 1
h-hook1
hHK1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 489-728 of human HOOK1 (NP_056972.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 51361
Gene Symbol HOOK1
Molecular Weight 84.648 kDa
Database Links HGNC:19884
OMIM:607820
Alternative Names Protein Hook homolog 1
h-hook1
hHK1
Function Required for spermatid differentiation, Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton , Component of the FTS/Hook/FHIP complex (FHF complex), The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) ,
Cellular Localization Cytoplasm,
Swiss-Prot Key Q9UJC3
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