| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSD17B4 (437-736) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSD17B4 |
| Gene ID: |
3295 |
| Uniprot ID: |
DHB4_HUMAN |
| Immunogen Region: |
437-736 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human HSD17B4 (NP_000405.1). |
| Immunogen Sequence: |
SGVVIIMDVYSYSEKELICH NQFSLFLVGSGGFGGKRTSD KVKVAVAIPNRPPDAVLTDT TSLNQAALYRLSGDWNPLHI DPNFASLAGFDKPILHGLCT FGFSARRVLQQFADNDVSRF KAIKARFAKPVYPGQTLQTE MWKEGNRIHFQTKVQETGDI VISNAYVDLAPTSGTSAKTP SEGGKLQSTFVFEEIGRRLK DIGPEVVKKVNAVFEWHITK GGNIGAKWTIDLKSGSGKV |
| Tissue Specificity | Present in many tissues with highest concentrations in liver, heart, prostate and testis. |
| Function | Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. |
| Protein Name | Peroxisomal Multifunctional Enzyme Type 2Mfe-217-Beta-Hydroxysteroid Dehydrogenase 417-Beta-Hsd 4D-Bifunctional ProteinDbpMultifunctional Protein 2Mfp-2Short Chain Dehydrogenase/Reductase Family 8c Member 1 Cleaved Into -3r-Hydroxyacyl-Coa Dehydrogenase - Enoyl-Coa Hydratase 23-Alpha -7-Alpha -12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-Coa Hydratase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-2046106Reactome: R-HSA-389887Reactome: R-HSA-390247Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Peroxisome |
| Alternative Antibody Names | Anti-Peroxisomal Multifunctional Enzyme Type 2 antibodyAnti-Mfe-2 antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase 4 antibodyAnti-17-Beta-Hsd 4 antibodyAnti-D-Bifunctional Protein antibodyAnti-Dbp antibodyAnti-Multifunctional Protein 2 antibodyAnti-Mfp-2 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 8c Member 1 Cleaved Into - antibodyAnti-3r-Hydroxyacyl-Coa Dehydrogenase - Enoyl-Coa Hydratase 2 antibodyAnti-3-Alpha -7-Alpha -12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-Coa Hydratase antibodyAnti-HSD17B4 antibodyAnti-EDH17B4 antibodyAnti-SDR8C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
