Anti-IER5 antibody

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Anti-IER5 antibody

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Product name Anti-IER5 antibody
Short Description Unconjugated goat polyclonal antibody against IER5.
Applications ELISA, WB
Dilution range ELISA-antibody detection limit dilution 1:2000.
WB-Customer's experiments gave a band at approx 45kDa in lysates of transfected H1299 overexpressing IER5 but not when transfected with empty vector. Recommended concentration: 1-3µg/ml.
Protein Name Immediate Early Response Gene 5 Protein
Immunogen Region Internal
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Goat
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 0.5 mg/ml
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Gene ID 51278
Gene Symbol IER5
Database Links HGNC:5393
OMIM:607177
Alternative Names Anti-Immediate Early Response Gene 5 Protein antibody
Anti-IER5 PP4583 SBBI48 antibody
Function Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter.
Cellular Localization Nucleus
Cytoplasm
Predominantly Cytoplasmic
Translocated In The Nucleus During Heat Shock
Tissue Specificity Expressed in acute myeloid leukemia (AML) cells.
Swiss-Prot Key IER5_HUMAN
Sequence QPPSGGEDDDAEE
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