| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFI30 (1-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFI30 |
| Gene ID: |
10437 |
| Uniprot ID: |
GILT_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2). |
| Immunogen Sequence: |
MTLSPLLLFLPPLLLLLDVP TAAVQASPLQALDFFGNGPP VNYKTGNLYLRGPLKKSNAP LVNVTLYYEALCGGCRAFLI RELFPTWLLVMEILNVTLVP YGNAQEQNVSGRWEFKCQHG EEECKFNKVEACVLDELDME LAFLTIVCMEEFEDMERSLP LCLQLYAPGLSPDTIMECAM GDRGMQLMHANAQRTDALQP PHEYVPWVTVNGKPLEDQTQ LLTLVCQLYQGKKPDVCPS |
| Post Translational Modifications | N-glycosylated. Sugar chains contain mannose-6-phosphate. Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases. |
| Function | Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. |
| Protein Name | Gamma-Interferon-Inducible Lysosomal Thiol ReductaseGamma-Interferon-Inducible Protein Ip-30Legumaturain |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-877300 |
| Cellular Localisation | SecretedLysosome |
| Alternative Antibody Names | Anti-Gamma-Interferon-Inducible Lysosomal Thiol Reductase antibodyAnti-Gamma-Interferon-Inducible Protein Ip-30 antibodyAnti-Legumaturain antibodyAnti-IFI30 antibodyAnti-GILT antibodyAnti-IP30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
