| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL12RB1 (25-305) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:200IF 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL12RB1 |
| Gene ID: |
3594 |
| Uniprot ID: |
I12R1_HUMAN |
| Immunogen Region: |
25-305 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1). |
| Immunogen Sequence: |
RTSECCFQDPPYPDADSGSA SGPRDLRCYRISSDRYECSW QYEGPTAGVSHFLRCCLSSG RCCYFAAGSATRLQFSDQAG VSVLYTVTLWVESWARNQTE KSPEVTLQLYNSVKYEPPLG DIKVSKLAGQLRMEWETPDN QVGAEVQFRHRTPSSPWKLG DCGPQDDDTESCLCPLEMNV AQEFQLRRRQLGSQGSSWSK WSSPVCVPPENPPQPQVRFS VEQLGQDGRRRLTLKEQPT |
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-12 Receptor Subunit Beta-1 antibodyAnti-Il-12 Receptor Subunit Beta-1 antibodyAnti-Il-12r Subunit Beta-1 antibodyAnti-Il-12r-Beta-1 antibodyAnti-Il-12rb1 antibodyAnti-Il-12 Receptor Beta Component antibodyAnti-Cd Antigen Cd212 antibodyAnti-IL12RB1 antibodyAnti-IL12R antibodyAnti-IL12RB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
