| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL17RE (24-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL17RE |
| Gene ID: |
132014 |
| Uniprot ID: |
I17RE_HUMAN |
| Immunogen Region: |
24-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-260 of human IL17RE (NP_705613.1). |
| Immunogen Sequence: |
AGIGFRHLPHWNTRCPLASH TDDSFTGSSAYIPCRTWWAL FSTKPWCVRVWHCSRCLCQH LLSGGSGLQRGLFHLLVQKS KKSSTFKFYRRHKMPAPAQR KLLPRRHLSEKSHHISIPSP DISHKGLRSKRTQPSDPETW ESLPRLDSQRHGGPEFSFDL LPEARAIRVTISSGPEVSVR LCHQWALECEELSSPYDVQK IVSGGHTVELPYEFLLPCLC IEASYLQEDTVRRKKCP |
| Tissue Specificity | Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. |
| Function | Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. |
| Protein Name | Interleukin-17 Receptor EIl-17 Receptor EIl-17re |
| Database Links | Reactome: R-HSA-448424 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: CytoplasmIsoform 3: SecretedIsoform 4: CytoplasmIsoform 5: Secreted |
| Alternative Antibody Names | Anti-Interleukin-17 Receptor E antibodyAnti-Il-17 Receptor E antibodyAnti-Il-17re antibodyAnti-IL17RE antibodyAnti-UNQ3056 antibodyAnti-PRO9877 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
