| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL24 (52-140) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL24 |
| Gene ID: |
11009 |
| Uniprot ID: |
IL24_HUMAN |
| Immunogen Region: |
52-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-140 of human IL24 (NP_001172085.1). |
| Immunogen Sequence: |
GQEFHFGPCQVKGVVPQKLW EAFWAVKDTMQAQDNITSAR LLQQEVLQNVSDAESCYLVH TLLEFYLKTVFKNYHNRTVE VRTLKSFST |
| Tissue Specificity | Up-regulated in melanoma cells induced to terminally differentiate. |
| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Melanoma Differentiation-Associated Gene 7 ProteinMda-7Suppression Of Tumorigenicity 16 Protein |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-24 antibodyAnti-Il-24 antibodyAnti-Melanoma Differentiation-Associated Gene 7 Protein antibodyAnti-Mda-7 antibodyAnti-Suppression Of Tumorigenicity 16 Protein antibodyAnti-IL24 antibodyAnti-MDA7 antibodyAnti-ST16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
