| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL31RA (20-321) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL31RA |
| Gene ID: |
133396 |
| Uniprot ID: |
IL31R_HUMAN |
| Immunogen Region: |
20-321 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_001284501.1). |
| Immunogen Sequence: |
VKPVLGIKRMIQIEWIKPEL APVSSDLKYTLRFRTVNSTS WMEVNFAKNRKDKNQTYNLT GLQPFTEYVIALRCAVKESK FWSDWSQEKMGMTEEEAPCG LELWRVLKPAEADGRRPVRL LWKKARGAPVLEKTLGYNIW YYPESNTNLTETMNTTNQQL ELHLGGESFWVSMISYNSLG KSPVATLRIPAIQEKSFQCI EVMQACVAEDQLVVKWQSSA LDVNTWMIEWFPDVDSEPT |
| Tissue Specificity | Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts. Detected in all of the myelomonocytic lineage. Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients. |
| Post Translational Modifications | N-glycosylated. |
| Function | Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. |
| Protein Name | Interleukin-31 Receptor Subunit AlphaIl-31 Receptor Subunit AlphaIl-31r Subunit AlphaIl-31r-AlphaIl-31raCytokine Receptor-Like 3Glm-RHglm-RGp130-Like Monocyte ReceptorGp130-Like ReceptorZcytor17 |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresynaptic Cell MembraneCell ProjectionAxon |
| Alternative Antibody Names | Anti-Interleukin-31 Receptor Subunit Alpha antibodyAnti-Il-31 Receptor Subunit Alpha antibodyAnti-Il-31r Subunit Alpha antibodyAnti-Il-31r-Alpha antibodyAnti-Il-31ra antibodyAnti-Cytokine Receptor-Like 3 antibodyAnti-Glm-R antibodyAnti-Hglm-R antibodyAnti-Gp130-Like Monocyte Receptor antibodyAnti-Gp130-Like Receptor antibodyAnti-Zcytor17 antibodyAnti-IL31RA antibodyAnti-CRL3 antibodyAnti-GPL antibodyAnti-UNQ6368 antibodyAnti-PRO21073 antibodyAnti-PRO21384 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
