• Western blot analysis of extracts of various cell lines, using IL36RN antibody (STJ110504) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

Anti-IL36RN antibody (1-155) (STJ110504)

SKU:
STJ110504

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IL36RN (1-155) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL36RN
Gene ID: 26525
Uniprot ID: I36RA_HUMAN
Immunogen Region: 1-155
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human IL36RN (NP_036407.1).
Immunogen Sequence: MVLSGALCFRMKDSALKVLY LHNNQLLAGGLHAGKVIKGE EISVVPNRWLDASLSPVILG VQGGSQCLSCGVGQEPTLTL EPVNIMELYLGAKESKSFTF YRRDMGLTSSFESAAYPGWF LCTVPEADQPVRLTQLPENG GWNAPITDFYFQQCD
Tissue Specificity Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Protein Name Interleukin-36 Receptor Antagonist Protein
Il-36ra
Fil1 Delta
Il-1-Related Protein 3
Il-1rp3
Interleukin-1 Hy1
Il-1hy1
Interleukin-1 Delta
Il-1 Delta
Interleukin-1 Family Member 5
Il-1f5
Interleukin-1 Receptor Antagonist Homolog 1
Il-1ra Homolog 1
Interleukin-1-Like Protein 1
Il-1l1
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Antibody Names Anti-Interleukin-36 Receptor Antagonist Protein antibody
Anti-Il-36ra antibody
Anti-Fil1 Delta antibody
Anti-Il-1-Related Protein 3 antibody
Anti-Il-1rp3 antibody
Anti-Interleukin-1 Hy1 antibody
Anti-Il-1hy1 antibody
Anti-Interleukin-1 Delta antibody
Anti-Il-1 Delta antibody
Anti-Interleukin-1 Family Member 5 antibody
Anti-Il-1f5 antibody
Anti-Interleukin-1 Receptor Antagonist Homolog 1 antibody
Anti-Il-1ra Homolog 1 antibody
Anti-Interleukin-1-Like Protein 1 antibody
Anti-Il-1l1 antibody
Anti-IL36RN antibody
Anti-FIL1D antibody
Anti-IL1F5 antibody
Anti-IL1HY1 antibody
Anti-IL1L1 antibody
Anti-IL1RP3 antibody
Anti-UNQ1896 antibody
Anti-PRO4342 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance