| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL6ST (678-857) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL6ST |
| Gene ID: |
3572 |
| Uniprot ID: |
IL6RB_HUMAN |
| Immunogen Region: |
678-857 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 678-857 of human IL6ST (NP_001177910.1). |
| Immunogen Sequence: |
PSISSSDENESSQNTSSTVQ YSTVVHSGYRHQVPSVQVFS RSESTQPLLDSEERPEDLQL VDHVDGGDGILPRQQYFKQN CSQHESSPDISHFERSKQVS SVNEEDFVRLKQQISDHISQ SCGSGQMKMFQEVSAADAFG PGTEGQVERFETVGMEAATD EGMPKSYLPQTVRQGGYMPQ |
| Tissue Specificity | Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. Isoform 2: Expressed in blood serum (at protein level). |
| Post Translational Modifications | Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated. Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding. |
| Function | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. Isoform 2: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response. Also blocks IL11 cluster signaling through IL11R. |
| Protein Name | Interleukin-6 Receptor Subunit BetaIl-6 Receptor Subunit BetaIl-6r Subunit BetaIl-6r-BetaIl-6rbCdw130Interleukin-6 Signal TransducerMembrane Glycoprotein 130Gp130Oncostatin-M Receptor Subunit AlphaCd Antigen Cd130 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-110056 P40189-1Reactome: R-HSA-112411 P40189-1Reactome: R-HSA-6788467Reactome: R-HSA-8984722Reactome: R-HSA-9020956 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-6 Receptor Subunit Beta antibodyAnti-Il-6 Receptor Subunit Beta antibodyAnti-Il-6r Subunit Beta antibodyAnti-Il-6r-Beta antibodyAnti-Il-6rb antibodyAnti-Cdw130 antibodyAnti-Interleukin-6 Signal Transducer antibodyAnti-Membrane Glycoprotein 130 antibodyAnti-Gp130 antibodyAnti-Oncostatin-M Receptor Subunit Alpha antibodyAnti-Cd Antigen Cd130 antibodyAnti-IL6ST antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
