| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IRF6 (115-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IRF6 |
| Gene ID: |
3664 |
| Uniprot ID: |
IRF6_HUMAN |
| Immunogen Region: |
115-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 115-300 of human IRF6 (NP_006138.1). |
| Immunogen Sequence: |
DIPQPQGSIINPGSTGSAPW DEKDNDVDEEDEEDELDQSQ HHVPIQDTFPFLNINGSPMA PASVGNCSVGNCSPEAVWPK TEPLEMEVPQAPIQPFYSSP ELWISSLPMTDLDIKFQYRG KEYGQTMTVSNPQGCRLFYG DLGPMPDQEELFGPVSLEQV KFPGPEHITNEKQKLFTSKL LDVMDR |
| Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. |
| Post Translational Modifications | Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. |
| Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. |
| Protein Name | Interferon Regulatory Factor 6Irf-6 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusCytoplasmTranslocates To Nucleus In Response To An Activating Signal |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 6 antibodyAnti-Irf-6 antibodyAnti-IRF6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
