| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ISY1 (1-307) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ISY1 |
| Gene ID: |
100534599/57461 |
| Uniprot ID: |
ISY1_HUMAN |
| Immunogen Region: |
1-307 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1). |
| Immunogen Sequence: |
MARNAEKAMTALARFRQAQL EEGKVKERRPFLASECTELP KAEKWRRQIIGEISKKVAQI QNAGLGEFRIRDLNDEINKL LREKGHWEVRIKELGGPDYG KVGPKMLDHEGKEVPGNRGY KYFGAAKDLPGVRELFEKER QVRWLMPVIPALWEAEAGGS QALPPPRKTRAELMKAIDFE YYGYLDEDDGVIVPLEQEYE KKLRAELVEKWKAEREARLA RGEKEEEEEEEEEINIYAV |
| Function | Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state. Involved in pre-mRNA splicing as component of the spliceosome. |
| Protein Name | Pre-Mrna-Splicing Factor Isy1 Homolog |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Isy1 Homolog antibodyAnti-ISY1 antibodyAnti-KIAA1160 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
