| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNH1 (813-962) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNH1 |
| Gene ID: |
3756 |
| Uniprot ID: |
KCNH1_HUMAN |
| Immunogen Region: |
813-962 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 813-962 of human KCNH1 (NP_002229.1). |
| Immunogen Sequence: |
FKDACGKSEDWNKVSKAESM ETLPERTKASGEATLKKTDS CDSGITKSDLRLDNVGEARS PQDRSPILAEVKHSFYPIPE QTLQATVLEVRHELKEDIKA LNAKMTNIEKQLSEILRILT SRRSSQSPQELFEISRPQSP ESERDIFGAS |
| Tissue Specificity | Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. |
| Post Translational Modifications | Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs). |
| Protein Name | Potassium Voltage-Gated Channel Subfamily H Member 1Ether-A-Go-Go Potassium Channel 1Eag Channel 1H-EagHeag1Voltage-Gated Potassium Channel Subunit Kv10.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneCell ProjectionDendriteAxonPresynaptic Cell MembranePerikaryonPostsynaptic Density MembraneEarly Endosome MembranePerinuclear Kcnh1 Is Located To Npc-Free Islands |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily H Member 1 antibodyAnti-Ether-A-Go-Go Potassium Channel 1 antibodyAnti-Eag Channel 1 antibodyAnti-H-Eag antibodyAnti-Heag1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv10.1 antibodyAnti-KCNH1 antibodyAnti-EAG antibodyAnti-EAG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
