Anti-KRT19 antibody

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Product name Anti-KRT19 antibody
Short Description Mouse monoclonal to KRT19
Description Cytokeratin 19 (CK19) forms intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue and provides mechanical support. Anti-Cytokeratin 19 stains epithelia and epithelial malignancies such as carcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Cytokeratin 19 is a useful marker for distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinoma. This differentiation is improved when stained in combination with Cytokeratin 7, CAM5.2l, Ber-EP4/MOC31, HepPar1 and TTF1. Cytokeratin 19 staining can also be used to recognize thyroid papillary carcinomas.
Applications IHC
Dilution range 1:100 - 1:200
Protein Name Keratin
type I cytoskeletal 19
Cytokeratin-19
CK-19
Keratin-19
K19
Immunogen Human Cytokeratin 19 protein.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC
Host Mouse
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Formulation Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Gene ID 3880
Gene Symbol KRT19
Molecular Weight 44.2 kDa
Database Links HGNC:6436
OMIM:148020
Reactome:R-HSA-6805567
Alternative Names Keratin antibody
type I cytoskeletal 19 antibody
Cytokeratin-19 antibody
CK-19 antibody
Keratin-19 antibody
K19 antibody
Function Involved in the organization of myofibers, Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue Specificity Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbi
Swiss-Prot Key P08727
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