Anti-LILRA4 antibody

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Product name Anti-LILRA4 antibody
Short Description Rabbit polyclonal against LILRA4
Description This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13. 4.
Applications WB
Dilution range WB 1:1000 - 1:2000
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4
Cd85 Antigen-Like Family Member G
Immunoglobulin-Like Transcript 7
Cd Antigen Cd85g
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 240-450 of human LILRA4 (NP_036408. 4).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 23547
Gene Symbol LILRA4
Molecular Weight Calculated: 47kDa/55kDa. Observed: 50kDa
Alternative Names Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 antibody
Anti-Cd85 Antigen-Like Family Member G antibody
Anti-Immunoglobulin-Like Transcript 7 antibody
Anti-Ilt-7 antibody
Anti-Cd Antigen Cd85g antibody
Anti-LILRA4 ILT7 antibody
Function Functions coreceptor to limit the innate immune responses to viral infections. signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
Cellular Localization Cell Membrane
Single-Pass Type I Membrane Protein
Tissue Specificity Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
Swiss-Prot Key LIRA4_HUMAN
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