| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LONP1 (120-400) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200IP 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LONP1 |
| Gene ID: |
9361 |
| Uniprot ID: |
LONM_HUMAN |
| Immunogen Region: |
120-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human LONP1 (NP_004784.2). |
| Immunogen Sequence: |
VFPHLPLIAITRNPVFPRFI KIIEVKNKKLVELLRRKVRL AQPYVGVFLKRDDSNESDVV ESLDEIYHTGTFAQIHEMQD LGDKLRMIVMGHRRVHISRQ LEVEPEEPEAENKHKPRRKS KRGKKEAEDELSARHPAELA MEPTPELPAEVLMVEVENVV HEDFQVTEEVKALTAEIVKT IRDIIALNPLYRESVLQMMQ AGQRVVDNPIYLSDMGAALT GAESHELQDVLEETNIPKR |
| Tissue Specificity | Duodenum, heart, lung and liver, but not thymus. |
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m. MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. |
| Protein Name | Lon Protease Homolog - MitochondrialLonhsLon Protease-Like ProteinLonpMitochondrial Atp-Dependent Protease LonSerine Protease 15 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Lon Protease Homolog - Mitochondrial antibodyAnti-Lonhs antibodyAnti-Lon Protease-Like Protein antibodyAnti-Lonp antibodyAnti-Mitochondrial Atp-Dependent Protease Lon antibodyAnti-Serine Protease 15 antibodyAnti-LONP1 antibodyAnti-PRSS15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
