| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LSS (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LSS |
| Gene ID: |
4047 |
| Uniprot ID: |
LSS_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3). |
| Immunogen Sequence: |
MTEGTCLRRRGGPYKTEPAT DLGRWRLNCERGRQTWTYLQ DERAGREQTGLEAYALGLDT KNYFKDLPKAHTAFEGALNG MTFYVGLQAEDGHWTGDYGG PLFLLPGLLITCHVARIPLP AGYREEIVRYLRSVQLPDGG WGLHIEDKSTVFGTALNYVS LRILGVGPDDPDLVRARNIL HKKGGAVAIPSWGKFWLAVL NVYSWEGLNTLFPEMWLFPD WAPAHPSTLWCHCRQVYLP |
| Tissue Specificity | Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels. |
| Function | Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. |
| Protein Name | Lanosterol Synthase2 -3-Epoxysqualene--Lanosterol CyclaseOxidosqualene--Lanosterol CyclaseOscHosc |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Lanosterol Synthase antibodyAnti-2 -3-Epoxysqualene--Lanosterol Cyclase antibodyAnti-Oxidosqualene--Lanosterol Cyclase antibodyAnti-Osc antibodyAnti-Hosc antibodyAnti-LSS antibodyAnti-OSC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89098/357557/STJ11100026_1__69013.1713121681.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and BUB1 knockout (KO) HeLa cells, using [KO Validated] BUB1 Rabbit polyclonal antibody (STJ11100026) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
