Anti-LZTS2 antibody

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Product name Anti-LZTS2 antibody
Short Description Rabbit polyclonal against LZTS2
Description The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Leucine Zipper Putative Tumor Suppressor 2
Protein Lapser1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 84445
Gene Symbol LZTS2
Molecular Weight Calculated: 72kDa. Observed: 73kDa
Alternative Names Anti-Leucine Zipper Putative Tumor Suppressor 2 antibody
Anti-Hlzts2 antibody
Anti-Protein Lapser1 antibody
Anti-LZTS2 KIAA1813 LAPSER1 antibody
Function Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Cellular Localization Cytoplasm
Microtubule Organizing Center
Localized To The Centrosome Throughout The Cell Cycle
Localized To The Midbody In Cells Undergoing Cytokinesis
Tissue Specificity Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
Swiss-Prot Key LZTS2_HUMAN
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