• Western blot analysis of extracts of mouse liver, using MEKK2 antibody (STJ117329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-MAP3K2 antibody (1-180) (STJ117329)

SKU:
STJ117329

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MAP3K2 (1-180) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP3K2
Gene ID: 10746
Uniprot ID: M3K2_HUMAN
Immunogen Region: 1-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human MEKK2 (NP_006600.3).
Immunogen Sequence: MDDQQALNSIMQDLAVLHKA SRPALSLQETRKAKSSSPKK QNDVRVKFEHRGEKRILQFP RPVKLEDLRSKAKIAFGQSM DLHYTNNELVIPLTTQDDLD KAVELLDRSIHMKSLKILLV INGSTQATNLEPLPSLEDLD NTVFGAERKKRLSIIGPTSR DRSSPPPGYIPDELHQVARN
Post Translational Modifications Autophosphorylated. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 2
Mapk/Erk Kinase Kinase 2
Mek Kinase 2
Mekk 2
Cellular Localisation Cytoplasm
Nucleus
Upon Egf Stimulation
Translocates Into The Nucleus
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 2 antibody
Anti-Mapk/Erk Kinase Kinase 2 antibody
Anti-Mek Kinase 2 antibody
Anti-Mekk 2 antibody
Anti-MAP3K2 antibody
Anti-MAPKKK2 antibody
Anti-MEKK2 antibody

Information sourced from Uniprot.org

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