| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MIF (1-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MIF |
| Gene ID: |
4282 |
| Uniprot ID: |
MIF_HUMAN |
| Immunogen Region: |
1-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human MIF (NP_002406.1). |
| Immunogen Sequence: |
MPMFIVNTNVPRASVPDGFL SELTQQLAQATGKPPQYIAV HVVPDQLMAFGGSSEPCALC SLHSIGKIGGAQNRSYSKLL CGLLAERLRISPDRVYINYY DMNAANVGWNNSTFA |
| Function | Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
| Protein Name | Macrophage Migration Inhibitory FactorMifGlycosylation-Inhibiting FactorGifL-Dopachrome IsomeraseL-Dopachrome TautomerasePhenylpyruvate Tautomerase |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedCytoplasmDoes Not Have A Cleavable Signal Sequence And Is Secreted Via A SpecializedNon-Classical PathwaySecreted By Macrophages Upon Stimulation By Bacterial Lipopolysaccharide (Lps)Or By MTuberculosis Antigens |
| Alternative Antibody Names | Anti-Macrophage Migration Inhibitory Factor antibodyAnti-Mif antibodyAnti-Glycosylation-Inhibiting Factor antibodyAnti-Gif antibodyAnti-L-Dopachrome Isomerase antibodyAnti-L-Dopachrome Tautomerase antibodyAnti-Phenylpyruvate Tautomerase antibodyAnti-MIF antibodyAnti-GLIF antibodyAnti-MMIF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
