| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTA3 (40-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTA3 |
| Gene ID: |
57504 |
| Uniprot ID: |
MTA3_HUMAN |
| Immunogen Region: |
40-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1). |
| Immunogen Sequence: |
AKVVCFYRRRDISNTLIMLA DKHAKEIEEESETTVEADLT DKQKHQLKHRELFLSRQYES LPATHIRGKCSVALLNETES VLSYLDKEDTFFYSLVYDPS LKTLLADKGEIRVGPRYQAD IPEMLLEGESDEREQSKLEV KVWDPNSPLTDRQIDQFLVV ARAVGTFARALDCSSSVRQP SLHMSAAAASRDITLFHAMD TLYRHSYDLSSAISVLVPLG GPVLCRDEMEEWSASEASL |
| Tissue Specificity | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. |
| Protein Name | Metastasis-Associated Protein Mta3 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Metastasis-Associated Protein Mta3 antibodyAnti-MTA3 antibodyAnti-KIAA1266 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
