| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MZB1 (1-189) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MZB1 |
| Gene ID: |
51237 |
| Uniprot ID: |
MZB1_HUMAN |
| Immunogen Region: |
1-189 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human MZB1 (NP_057543.2). |
| Immunogen Sequence: |
MRLSLPLLLLLLGAWAIPGG LGDRAPLTATAPQLDDEEMY SAHMPAHLRCDACRAVAYQM WQNLAKAETKLHTSNSGGRR ELSELVYTDVLDRSCSRNWQ DYGVREVDQVKRLTGPGLSE GPEPSISVMVTGGPWPTRLS RTCLHYLGEFGEDQIYEAHQ QGRGALEALLCGGPQGACSE KVSATREEL |
| Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. |
| Post Translational Modifications | Forms an interchain disulfide bond with IgM monomers. |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
| Protein Name | Marginal Zone B- And B1-Cell-Specific ProteinMesenteric Estrogen-Dependent Adipose 7Meda-7Plasma Cell-Induced Resident Endoplasmic Reticulum ProteinPlasma Cell-Induced Resident Er ProteinPerp1Proapoptotic Caspase Adapter Protein |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum LumenSecretedIsoform 2: CytoplasmDiffuse Granular Localization In The Cytoplasm Surrounding The Nucleus |
| Alternative Antibody Names | Anti-Marginal Zone B- And B1-Cell-Specific Protein antibodyAnti-Mesenteric Estrogen-Dependent Adipose 7 antibodyAnti-Meda-7 antibodyAnti-Plasma Cell-Induced Resident Endoplasmic Reticulum Protein antibodyAnti-Plasma Cell-Induced Resident Er Protein antibodyAnti-Perp1 antibodyAnti-Proapoptotic Caspase Adapter Protein antibodyAnti-MZB1 antibodyAnti-MEDA7 antibodyAnti-PACAP antibodyAnti-HSPC190 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
