Anti-NDUFA13 antibody

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Product name Anti-NDUFA13 antibody
Short Description Rabbit polyclonal against NDUFA13
Description This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13
Cell Death Regulatory Protein Grim-19
Complex I-B16.6
Ci-B16.6
Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein
Grim-19
Gene Associated With Retinoic And Ifn-Induced Mortality 19 Protein
Nadh-Ubiquinone Oxidoreductase B16.6 Subunit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 52-144 of human NDUFA13 (NP_057049. 5).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 51079
Gene Symbol NDUFA13
Molecular Weight Calculated: 16kDa/24kDa. Observed: 17kDa
Database Links Reactome: R-HSA-611105
Alternative Names Anti-Nadh Dehydrogenase Ubiquinone 1 Alpha Subcomplex Subunit 13 antibody
Anti-Cell Death Regulatory Protein Grim-19 antibody
Anti-Complex I-B16.6 antibody
Anti-Ci-B16.6 antibody
Anti-Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein antibody
Anti-Grim-19 antibody
Anti-Gene Associated With Retinoic And Ifn-Induced Mortality 19 Protein antibody
Anti-Nadh-Ubiquinone Oxidoreductase B16.6 Subunit antibody
Anti-NDUFA13 GRIM19 CDA016 CGI-39 antibody
Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Cellular Localization Mitochondrion Inner Membrane
Single-Pass Membrane Protein
Matrix Side
Nucleus
Localizes Mainly In The Mitochondrion
May Be Translocated Into The Nucleus Upon Ifn/Ra Treatment
Tissue Specificity Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
Swiss-Prot Key NDUAD_HUMAN
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