Anti-NDUFA4 antibody

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Product name Anti-NDUFA4 antibody
Short Description Rabbit polyclonal against NDUFA4
Description Rabbit polyclonal to NDUFA4.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:300
ELISA 1:10000
Specificity NDUFA4 Polyclonal Antibody detects endogenous levels of NDUFA4 protein.
Protein Name Cytochrome C Oxidase Subunit Ndufa4
Complex I-Mlrq
Ci-Mlrq
Nadh-Ubiquinone Oxidoreductase Mlrq Subunit
Immunogen Synthesized peptide derived from human NDUFA4
Immunogen Region 10-90 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC WB
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4697
Gene Symbol NDUFA4
Molecular Weight 9 kDa
Database Links HGNC:7687
OMIM:256000
Alternative Names Anti-Cytochrome C Oxidase Subunit Ndufa4 antibody
Anti-Complex I-Mlrq antibody
Anti-Ci-Mlrq antibody
Anti-Nadh-Ubiquinone Oxidoreductase Mlrq Subunit antibody
Anti-NDUFA4 antibody
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
Cellular Localization Mitochondrion Inner Membrane
Single-Pass Membrane Protein
Swiss-Prot Key NDUA4_HUMAN
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