Anti-NLRP7 antibody

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Product name Anti-NLRP7 antibody
Short Description Rabbit polyclonal against NLRP7
Description This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Nacht-Lrr And Pyd Domains-Containing Protein 7
Nucleotide-Binding Oligomerization Domain Protein 12
Pyrin-Containing Apaf1-Like Protein 3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_631915. 2).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 199713
Gene Symbol NLRP7
Molecular Weight Calculated: 111kDa/114kDa/118kDa. Observed: 110kDa
Alternative Names Anti-Nacht-Lrr And Pyd Domains-Containing Protein 7 antibody
Anti-Nucleotide-Binding Oligomerization Domain Protein 12 antibody
Anti-Pyrin-Containing Apaf1-Like Protein 3 antibody
Anti-NLRP7 NALP7 NOD12 PYPAF3 antibody
Function Inhibits CASP1/caspase-1-dependent IL1B secretion.
Tissue Specificity Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
Swiss-Prot Key NALP7_HUMAN
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