Anti-NR2F6 Antibody

[STJ117466] Download PDF Print Data Sheet

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Product name Anti-NR2F6 Antibody
Short Description Rabbit polyclonal against NR2F6
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Nuclear receptor subfamily 2 group F member 6
V-erbA-related protein 2
EAR-2
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human NR2F6 (NP_005225.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 2063
Gene Symbol NR2F6
Molecular Weight 42.979 kDa
Database Links HGNC:7977
OMIM:132880
Reactome:R-HSA-383280
Alternative Names Nuclear receptor subfamily 2 group F member 6
V-erbA-related protein 2
EAR-2
Function Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock
Cellular Localization Nucleus
Tissue Specificity Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas
Swiss-Prot Key P10588
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